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In this work, we found by quantitative proteomics that histone Ser-ADPr is reversible in cells during response to DNA damage. We recently discovered a new form of ADPr that is attached to serine residues in target proteins (Ser-ADPr) and showed that this PTM is specifically made by PARP1/HPF1 and PARP2/HPF1 complexes. A number of proteins catalyse the transfer and hydrolysis of ADPr, and also specify how and when the modification is conjugated to the targets. St.ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls many cellular processes, including DNA repair, transcription, chromatin regulation and mitosis.“Radiation Therapy – Erectile Dysfunction”.
![reversed ed version reversed ed version](https://venturebeat.com/wp-content/uploads/2020/01/dario-gil.jpg)
![reversed ed version reversed ed version](https://i1.sndcdn.com/artworks-000413967603-89cban-t500x500.jpg)
The term venous leakage refers to veins in the penis.īlood vessels are important for erections. Problems with blood vessels are a common cause of erectile dysfunction (ED).